Pdgfrb-creert2
SpletThe PDGFRB gene is located on human chromosome 5 at position q32 (designated as 5q32) and contains 25 exons. The gene is flanked by the genes for granulocyte-macrophage colony-stimulating factor and Colony stimulating factor 1 receptor (also termed macrophage-colony stimulating factor receptor), all three of which may be lost together … SpletTamoxifen (TAM)-inducible Cre recombinase (Cre-ERT2) is widely used for tissue-specific and temporal induction of gene deletion in mice. However, the tamoxifen treatment regimen for the generation...
Pdgfrb-creert2
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SpletPDGF receptor α (PDGFRα) is expressed specifically in the embryonic day 7.5 (E7.5) mesoderm and in the E9.5 neural crest among other tissues. PDGFRα-expressing cells … SpletPDGF receptor α (PDGFRα) is expressed specifically in the embryonic day 7.5 (E7.5) mesoderm and in the E9.5 neural crest among other tissues. PDGFRα-expressing cells and their descendants are involved in the formation of various tissues. To trace PDGFRα-expressing cells in vivo, we generated a knock-in mouse line that expressed a fusion ...
SpletPDGFRβ-P2A-CreER T2 mice: a genetic tool to target pericytes in angiogenesis Angiogenesis. 2024 Nov;20 (4):655-662. doi: 10.1007/s10456-017-9570-9. Epub 2024 Jul … Splet029684 B6.Cg-Tg(Pdgfrb-cre/ERT2)6096Rha/J Pdgfr-β-CreER T2 transgenic mice express tamoxifen-inducible Cre recombinase under the direction of the murine platelet derived …
Splet16. nov. 2024 · For transduction of conditional Cre mice, the AAV-FLEx virus (10 11 GC per mouse) was injected into 6- to 8-week-old hemizygous Pdgfrb-P2A-creERT2 or LysM-creERT2 male mice. Splet14. sep. 2016 · We report that Pdgfrα-CreERT2 transgenic mice are highly suitable for OPC-directed gene recombination in the CNS, can be used to achieve robust recombination in OPCs, induce moderate recombination in PDGFRα + bone marrow stromal cells, and have a minimal effect on other PDGFRα + cell populations. Materials and Methods Transgenic …
Splet28. sep. 2024 · 作为脑内最早感受系统炎症并对其做出反应的细胞类型，PDGFRβ细胞（Col1a1 和/或Rgs5亚型）是治疗中枢神经系统感染的潜在新靶点。 由于其位于脑实质与循环系统界面的特殊位置，靶向PDGFRβ细胞等血脑屏障组成细胞的药物有不需要跨过血脑屏障的优势。 该研究由博士研究生段力辉、张小荻在研究员于翔的指导下完成，实验室成员 …
SpletPlatelet-derived growth factor B (PDGFB) is a high affinity ligand for PDGFB receptors PDGFB A and B. Pdgfb is expressed in ECs, where it is crucial for the proper arrangements of pericytes and smooth muscle cells in the vessel wall. 53 However, Pdgfb is neither exclusively nor ubiquitously expressed in the vasculature: expression is observed in … sugar style walkthroughSplet17. nov. 2024 · Pdgfrb-CreERT2 ROSA-DTA double transgenic mice displayed a strong reduction in bodyweight and failed to survive beyond the first week of postnatal life, … paint your own pottery fort wayne inpaint your own pottery frederick mdSplet09. mar. 2024 · To deplete pericytes, Pdgfrb-CreERT2/iDTR and its control (iDTR) mice were given DT intraperitoneally once every 24 hours at a dose of 10 ng/g on 4 consecutive days after tamoxifen administration. All transgenic mice in this study were validated and genotyped. Both male and female mice were used, and all mice used were adults aged … paint your own pottery friscoSpletCre-mediated recombination occurs in a small number of adult hematopoietic stem cells in Pdgfb-iCreERT2;JAK2 V617F/WT transgenic mice. SUMMARY: Background The vessel … sugar substitute in protein shakesSplet04. apr. 2024 · This BAC was modified to insert a creER fusion gene (a cre recombinase fused to a human estrogen receptor ligand-binding domain) into the start codon of … paint your own pottery glasgowSplet13. maj 2024 · Atf6aPdgfrbCreERT2 mice were also crossed with Ire1afl/fl mice to generate Atf6afl/flIre1afl/fl or Atf6afl/flIre1afl/flPdgfrbCreERT2 mice. To induce recombination of floxed alleles, 10–12-wk-old mice received tamoxifen via intraperitoneal (IP) injections (75 mg/kg for 5 consecutive days). paint your own pottery fort worth