2024 Cisplatin apoptosis induction concentration

Cisplatin apoptosis induction concentration

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August undefined, 2024

WebJan 16, 2024 · In the experimental group, with a concentration of 0.1 g/ml of cisplatin, about 37% of the cells were alive and about 6% of the cells had primary apoptosis. More than 42% of the cells had secondary apoptosis and about 14% of the cells had necrosis. WebMar 9, 2024 · The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, apoptosis, oxidative stress, inflammation, and vascular injury in the kidneys. At present, there are no effective drugs or methods for cisplatin-induced kidney injury.

Current Oncology Free Full-Text Blockade of ALDH in …

WebWe previously described that blocking ALDH activity enhances the induction of apoptosis, especially in ovarian cancer stem cells treated with chemotherapeutic agents. ... According to Table 1, the combination of cisplatin at the concentration of 0.4 µM, which is a reduction by 51.06-fold from 22 µM, with paclitaxel at 0.03 µM, ... WebCisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin forms inter- and intrastrand crosslinked DNA adducts … playmate tennis ball machine control board

Methoxyphenyl chalcone sensitizes aggressive epithelial cancer to ...

WebApr 28, 2011 · For all cell lines, it is true that concentrations of cisplatin up to 30μM caused mainly a mode of cell death with clear morphological and biochemical characteristics of apoptosis, whereas the commonest phenotype observed with concentrations equal or higher than 300μM had clearly lost many of these characteristics and more closely … WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … WebJan 1, 2007 · Cisplatin is a broad-spectrum anticancer drug that is also widely used in experimental studies on DNA damage-induced apoptosis. Induction of apoptosis … prime ministers of usa

Acute apoptosis by cisplatin requires induction of reactive oxyge…

Current Oncology Free Full-Text Blockade of ALDH in Cisplatin ...

WebOct 13, 2024 · Cisplatin is mainly cleared by the kidney through glomerular filtration and tubular excretion, resulting in a higher concentration of this drug in the kidney than in … WebA high concentration of cisplatin induces apoptosis in many tumor cell lines. Whether cisplatin induces apoptosis even in a controlled release formulation has not been … prime minister south africa 1919WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … playmate tennis ball machine parts

"WebJul 1, 1999 · Treatment of each cell line with IC 90 concentrations of cisplatin yielded clear cleavage of procaspase-3 in the CP70 and C30 cells, whereas we were still unable to … " - Cisplatin apoptosis induction concentration

Cisplatin apoptosis induction concentration

Cisplatin-induced hydroxyl radicals mediate pro-survival …

WebMar 17, 2016 · Induction of ROS-dependent apoptosis by cisplatin combined with gallic acid (GA) in H446 cells. (A) Apoptosis assay by flow cytometry using PI and Annexin V-FITC double staining. H446 cells were treated with or without 6 mM NAC for 2 h before challenge with 5 µg/ml cisplatin combined with 3 µg/ml GA for 24 h. WebNov 7, 2024 · Cisplatin efficiently induced cell death in OVCAR-3, OVCAR-4, and IRGOV-1 (>60% cell death) whereas OVCAR-5, OVCAR-8, and A2780 showed <30% apoptotic cells in response to cisplatin. Based on...

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WebMar 1, 2006 · The chloride ions in cisplatin are particularly important in its action as a drug. They are relatively stable when the drug is outside the cell, where the chloride concentration is normally high. But when the drug gets inside the cell and the chloride concentration drops, cisplatin loses its two chlorides, and they are replaced by water … WebThe anticancer drug cisplatin induces cell death by apoptosis. Apoptosis is dependent on cellular loss of potassium ions (K+). We have recently shown that the antifungal drug amphotericin B (enhancin

WebCisplatin at concentrations of 1 μM and 2 μM induces DNA damage but not excessive apoptosis in hESC. Cells were treated with cisplatin at concentrations ranging from 1 μM to10 μM for 24 hours... WebSep 1, 2024 · CDDP had differential effect on proteins expression and induced apoptosis in GC cells. a Western blot shows the effect of CDDP on protein expression in AGS and NCI - N87 cell lines. The expression of tumor suppressor protein 53 increased with CDDP concentration, whilst Akt and NFkB expressions reduced, notice the cleaved PARP …

WebJan 16, 2024 · In the experimental group, with a concentration of 0.1 g/ml of cisplatin, about 37% of the cells were alive and about 6% of the cells had primary apoptosis. … WebJul 28, 2024 · The present study indicated that cisplatin at the maximum response concentration mediated autophagy through the induction of OH ·, which subsequently …

WebApr 28, 2011 · Cisplatin is a chemotherapeutic drug widely used in the treatment of a variety of cancers, including sarcomas, lymphomas, and some carcinomas such as small …

WebJan 18, 2016 · Cisplatin induces apoptosis in renal tubular cells. (A and B) NRK-52E cells treated with or without (Ctrl) different concentrations of cisplatin (10–50 μmol/L) for 24 h were subjected to phase ... prime minister southWebApoptosis inducers act on several apoptosis-related proteins to promote apoptotic cell death. Depending on the agent selected and the concentrations used, apoptotic events … prime minister south parkWebJul 3, 2024 · A single injected dose of cisplatin has been commonly used in that it is effective and practical at concentrations ranging from 10 to 30 mg/kg, as shown in Table 1. However, this approach is not similar to clinical chemotherapy in which cisplatin is administered as a single intravenous dose every 4 to 6 weeks with as many as six … prime minister south africa 1919-24WebMay 3, 2024 · MTC induces apoptosis in ovarian cancer cells. (a) Photomicrographs of ES-2 cells treated with MTC for 24 h showed the concentration-dependent effect on cytotoxicity. Immunofluorescent staining to identify cleaved-PARP was performed to represent caspase activity. prime ministers of united kingdomWebOct 5, 2014 · Cisplatin is stable under normal temperatures and pressures, but may transform slowly over time to the trans-isomer (IARC 1981, Akron 2009). Cisplatin has a … playmate toddler bed plasticWebSep 30, 2024 · Induction of apoptosis and DNA damage response were evaluated in both monotherapy and combination therapy groups. Results: Results demonstrate that … prime ministers over last 100 yearsWebOct 22, 2024 · Cisplatin is an alkylating agent which induces DNA damage through the formation of cisplatin-DNA adducts, leading to cell cycle arrest and apoptosis. In the … prime ministers pay 2022